January 6, 2012Journal of Applied Physiology

Sympathetic activation by chemical stimulation of white adipose tissues in rats

View Full Paper

Ask AI

Bookmark

Why the study?

Does chemical stimulation of white adipose tissue increase sympathetic outflow and blood pressure in rats?

Population

Anesthetized rats

Comparison

Injection of capsaicin, bradykinin, adenosine… vs Intravenous, intramuscular, or intradermal…

Design

Preclinical

Authors

ZSZhen ShiSoochow University WCWeiwei ChenNanjing University of Chinese Medicine XXXiao‐Qing XiongNanjing Medical University

Discussion

Member takes

Implication

Supports adipose afferent reflexes in rat sympathetic control; leaves open translation to human hypertension or obesity.

Structured PICO

Does chemical stimulation of white adipose tissue increase sympathetic outflow and blood pressure in rats?

Population

Anesthetized rats

Intervention

Injection of capsaicin, bradykinin, adenosine, ATP, or leptin into inguinal white adipose tissue (iWAT) or retroperitoneal white adipose tissue (rWAT)

Comparator

Intravenous, intramuscular, or intradermal injection of capsaicin; iWAT denervation or chemical lesion of the PVN neurons

Outcome

Renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP)surrogate

Chemical stimulation of white adipose tissue afferents reflexly increases renal sympathetic nerve activity and blood pressure via pathways involving the paraventricular nucleus in rats.

Cite This Study

Shi et al. (2012) studied this question.

synapsesocial.com/papers/6a8563e0734852141cd4cb64 https://doi.org/10.1152/japplphysiol.01164.2011

View Full Paper

Ask AI

Bookmark

Sympathetic activation by chemical stimulation of white adipose tissues in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sympathetic activation by chemical stimulation of white adipose tissues in rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider