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August 19, 2026Advanced Synthesis & Catalysis

Synthetic Advances of Five‐Membered N‐Heterocycles via Amino‐Based Organocatalysis

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Authors

RSRajeev SinghADAshutosh DixitNANaseem Ahmed

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Overview

Review highlights amine-based organocatalysis for constructing five-membered nitrogen heterocycles, indicating efficient and sustainable pathways for drug discovery and materials science.

Key Points

  • To review the development, synthetic strategies, and mechanistic insights of amine-based organocatalytic methodologies for constructing five-membered nitrogen heterocycles over the last 15 years.
  • Surveyed amine-catalyzed and metal-synergistic synthetic routes for five-membered nitrogen heterocycles published across a 15-year period.
  • Evaluated reaction mechanisms, operational conditions, and parameters governing regio- and stereoselectivity in one-pot and multicomponent cascades.
  • Amine-based organocatalysts facilitate the efficient construction of diverse scaffolds, including pyrroles, pyrazoles, imidazoles, 1,2,3-triazoles, 1,2,4-triazoles, and tetrazoles.
  • Methodologies consistently operate under mild conditions with high regio- and stereoselectivity, offering operational simplicity, air and moisture tolerance, low toxicity, and reduced environmental impact.

Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/6a8563eb03308d306e2d7573https://doi.org/10.1002/adsc.70717
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