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August 19, 2026GeriatricsOpen Access

How Gut Microbiota Influence Healthy Aging: Overview of Reviews

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Authors

TTTejas Ganesh TodmalUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”RBRabia BibiUniversità degli Studi del Piemonte Orientale “Amedeo Avogadro”GCGiovanni CangelosiUniversità di Camerino

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Overview

Overview of reviews demonstrates that microbiome-targeted diets improve metabolic, immune, and cognitive health in adults, suggesting dietary strategies promote healthy longevity.

Key Points

  • Synthesize existing review-level evidence on how dietary and lifestyle interventions modify gut microbiota composition to influence healthy aging outcomes.
  • Conducted an overview of reviews following PRISMA guidelines across PubMed and Scopus for English-language syntheses published between January 2023 and October 2025.
  • Included reviews focusing on adults aged ≥18 years evaluating dietary or lifestyle interventions with reported gut microbiota and healthy-aging parameters.
  • Assessed methodological quality of included reviews using the SANRA appraisal tool.
  • Mediterranean and plant-based diets, calorie restriction, prebiotics, probiotics, synbiotics, and fecal microbiota transplantation enriched short-chain fatty acid producers (Faecalibacterium, Bifidobacterium, Lactobacillus, Akkermansia muciniphila) and reduced pro-inflammatory taxa.
  • Microbiome restructuring was associated with improved metabolic regulation, enhanced immune competence, reduced inflammaging, lower frailty, and superior physical resilience.
  • Interventions were linked to reduced neuroinflammation and decreased risk profiles for Alzheimer's and Parkinson's diseases.

Cite This Study

Todmal et al. (2026) studied this question.

synapsesocial.com/papers/6a8563eb03308d306e2d7640https://doi.org/10.3390/geriatrics11040107
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