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August 19, 2026Animal Models and Experimental MedicineOpen Access

Adipose‐derived mesenchymal stem cell injection into the KI10 acupoint mitigates cartilage damage in KOA rats through PGE2 ‐mediated α7nAChR / NF ‐ κB pathway

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Authors

MDMengwei DongWLWenfang LiWYWanpeng Yang

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Overview

Animal study demonstrates that acupoint-targeted stem cell injection reduces cartilage damage in osteoarthritic rats, highlighting a synergistic regenerative approach.

Key Points

  • To evaluate the therapeutic efficacy and underlying molecular mechanisms of adipose-derived mesenchymal stem cell (ADSC) injection into the KI10 acupoint for treating knee osteoarthritis.
  • Established knee osteoarthritis in male Sprague-Dawley rats and administered ADSC injections directly into the KI10 acupoint.
  • Assessed pain behavior, motor function, histopathology, and chondrocyte ultrastructure alongside TMT-based proteomic profiling.
  • Validated the involved pathway pharmacologically using the α7nAChR antagonist methyllycaconitine citrate (MLA).
  • ADSC injection into KI10 significantly alleviated joint pain, improved motor performance, and reduced synovial inflammation and cartilage degeneration.
  • Ultrastructural and proteomic analyses showed reduced chondrocyte damage and activation of the PGE2-mediated α7nAChR/NF-κB anti-inflammatory pathway.
  • Administration of MLA reversed the protective and anti-inflammatory benefits of the ADSC acupoint intervention.

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/6a85640f03308d306e2d798bhttps://doi.org/10.1002/ame2.70220
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Adipose mesenchymal stem cells derived exosomes ameliorates KOA cartilage damage and inflammation by activation of PINK1-mediated mitochondrial autophagy2024 · 2 citations
  2. 2Evaluation of an AD-MSC Supernatant-Loaded Thermosensitive Hydrogel for Cartilage Protection in Osteoarthritis2026 · 2 citations
  3. 3Mechanism of acupoint penetration acupuncture therapy regulating chondrocyte autophagy via the PI3K/Akt-mTOR pathway in KOA rats2024 · 2 citations
  4. 4Uncovering the mechanisms of homologous point acupuncture on knee osteoarthritis through an integrated study of metabolomics and proteomics2026
  5. 5Acupotomy Ameliorates Articular Cartilage Fibrosis in a Rabbit Model of Knee Osteoarthritis via the TGF-β1/Smad Pathway2026