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August 19, 2026Hypertension in PregnancyOpen Access

MIR210HG promotes preeclampsia progression through CDHR5

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Authors

NSNingxia SunLZLu ZhangJXJine Xu

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Overview

Case-control study reveals elevated blood MIR210HG and placental CDHR5 in preeclampsia, indicating non-invasive biomarker potential.

Key Points

  • To investigate the expression patterns, phenotypic specificity, and non-invasive diagnostic utility of long non-coding RNA MIR210HG and its functional relationship with CDHR5 in preeclampsia.
  • Analyzed peripheral blood and placental tissues from 88 preeclampsia patients and 81 normal pregnant controls recruited between January 2020 and December 2021.
  • Evaluated MIR210HG and CDHR5 expression using RT-PCR and western blotting, and performed in vitro knockdown and overexpression assays in human trophoblasts (Bewo, JEG3) and endothelial cells.
  • Peripheral blood MIR210HG was specifically upregulated in early-onset preeclampsia and showed superior diagnostic efficacy for the preeclampsia-fetal growth restriction subtype.
  • Placental CDHR5 expression was significantly elevated in preeclampsia cases compared to normal controls (P = 0.004).
  • MIR210HG knockdown significantly decreased CDHR5 expression in Bewo (P = 0.019) and JEG3 (P = 0.006) trophoblasts, and CDHR5 knockdown also downregulated MIR210HG in Bewo cells (P = 0.023).

Cite This Study

Sun et al. (2026) studied this question.

synapsesocial.com/papers/6a85642503308d306e2d7c76https://doi.org/10.1080/10641955.2026.2708180
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