What question did this study set out to answer?

To evaluate real-world diagnostic pathways, molecular profiles, referral patterns, and treatment heterogeneity in adults managed for Langerhans cell histiocytosis across multiple Canadian centers.

August 19, 2026Hematological OncologyOpen Access

Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series

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Authors

SQStephanie QuonUniversity of British Columbia YGYaswanta GummadiDalhousie University IEIbrahim ElsharawiDalhousie University

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Implication

Retrospective multicenter study reports clinical heterogeneity, frequent BRAF mutations, and varied therapies in adults with Langerhans cell histiocytosis, highlighting the need for standardized care.

Key Points

To evaluate real-world diagnostic pathways, molecular profiles, referral patterns, and treatment heterogeneity in adults managed for Langerhans cell histiocytosis across multiple Canadian centers.
Conducted a retrospective review of an adult-care cohort (N=31) with histologically confirmed Langerhans cell histiocytosis diagnosed between 2000 and 2025 across multiple Canadian centers, including patients transitioned from pediatric care.
Analyzed clinical presentations, radiologic and histopathologic findings, molecular testing results, and systemic therapy regimens.
The median age at diagnosis was 42 years (range: 2–84) with 65% males; primary involvement sites included bone (74%), lung (29%), and skin (16%), while 19% had concomitant or subsequent malignancies.
BRAFV600E mutations were identified in 44% of tested patients, and the most common first-line systemic regimen was cytarabine (n = 10), alongside hydroxyurea, vemurafenib, and cladribine.

Cite This Study

Quon et al. (2026) studied this question.

synapsesocial.com/papers/6a85643903308d306e2d7cbd https://doi.org/10.1002/hon.70241

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Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series

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Implication

Key Points

Cite This Study

Langerhans Cell Histiocytosis in Adults: A Canadian Multicenter Case Series

Discussion

Member takes

Implication

Key Points

Cite This Study

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