What question did this study set out to answer?

To determine whether rising Mycoplasma pneumoniae incidence in endemic and epidemic settings is driven by single or multiple genotypes and to evaluate macrolide resistance patterns.

June 6, 2012PLoS ONEOpen Access

The Spread of Mycoplasma pneumoniae Is Polyclonal in Both an Endemic Setting in France and in an Epidemic Setting in Israel

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Authors

SPSabine PereyreCentre National de la Recherche Scientifique ACAlain CharronInstitut National de la Recherche Agronomique CHCarlos Hidalgo‐GrassHebrew University of Jerusalem

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Implication

Molecular typing reveals polyclonal spread of Mycoplasma pneumoniae in endemic and epidemic cohorts, indicating diverse strains drive outbreaks rather than single-clone expansion.

Key Points

To determine whether rising Mycoplasma pneumoniae incidence in endemic and epidemic settings is driven by single or multiple genotypes and to evaluate macrolide resistance patterns.
Modified and validated a culture-free multilocus variable-number tandem-repeat analysis (MLVA) assay for direct molecular typing of respiratory tract specimens.
Tested 34 M. pneumoniae-positive specimens collected during an endemic period in France (2007–2010) and 63 specimens collected during an epidemic surge in Israel (2010).
Screened specimens for the A2058G point mutation conferring macrolide resistance and evaluated associations with specific MLVA genotypes.
M. pneumoniae spread was polyclonal across both settings, comprising 15 distinct MLVA types in France and 18 distinct MLVA types in Israel.
Macrolide resistance linked to the A2058G substitution was identified in 22% of Israeli patients, spanning four MLVA types.
MLVA type Z represented the predominant resistant variant, showing an association with macrolide resistance present initially or acquired during infection.

Cite This Study

Pereyre et al. (2012) studied this question.

synapsesocial.com/papers/6a85667b581d4f62e2d59dcd https://doi.org/10.1371/journal.pone.0038585

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Implication

Molecular typing reveals polyclonal spread of Mycoplasma pneumoniae in endemic and epidemic cohorts, indicating diverse strains drive outbreaks rather than single-clone expansion.

The Spread of Mycoplasma pneumoniae Is Polyclonal in Both an Endemic Setting in France and in an Epidemic Setting in Israel

Discussion

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Implication

Key Points

Cite This Study

The Spread of Mycoplasma pneumoniae Is Polyclonal in Both an Endemic Setting in France and in an Epidemic Setting in Israel

Discussion

Member takes

Implication

Key Points

Cite This Study

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