Ciprofloxacin-ResistantSalmonella entericaSerotype Typhimurium, China

We characterized 44 Salmonella enterica serotype Typhimurium isolates from Tongji Hospital outpatients in Wuhan, China, May 2002-October 2005.All 31 ciprofl oxacin-resistant isolates were also resistant to >8 other antimicrobial drugs and carried >2 mutations in GyrA and 1 mutation in ParC.Class 1 integrons were identifi ed in 37 isolates.S almonellae are a common cause of community-acquired foodborne bacterial gastroenteritis worldwide.The incidence of Salmonella infections in the People's Republic of China has not been well documented.However, in the United States, ≈1.4 million persons are infected by Salmonella spp. each year (1).Although >2,500 serotypes have been reported, Salmonella enterica serotype Typhimurium is 1 of the leading serotypes causing salmonellosis worldwide (2).Fluoroquinolones such as ciprofl oxacin are strongly recommended for treatment of severe S. Typhimurium infections in adults (3).In this study, we characterized all S. Typhimurium isolates recovered from May 2002 through October 2005 from outpatients of Tongji Hospital, Wuhan, China, a sentinel hospital in the National Center for Surveillance of Antimicrobial Resistance.During the time of this study, Tongji Hospital strictly followed the recommendation for treatment of severe S. Typhimurium infections.