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October 1, 1974Journal of Cellular Physiology

Electrical sizing of particles in suspensions IV. Lymphocytes

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Authors

SBShmuel A. Ben‐SassonNational Institutes of HealthDPDeborah PatinkinHebrew University of JerusalemNGN.B. GroverNew Jersey Urology

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Implication

Experimental analysis reveals normally distributed diameters in human lymphocytes, suggesting unique physical properties absent in leukemic cells.

Key Points

  • To assess electrical resistance pulse sizing principles for measuring lymphocyte volume and establish whether cells conform to rigid, non-conducting sphere models.
  • Evaluated theoretical particle-orifice interaction models under an electric field to identify criteria for simplified cell volume measurement.
  • Measured volume and diameter distributions of lymphocytes from chick blood and lymphatic organs, mouse tissues, healthy humans, and human patients with chronic lymphatic leukemia.
  • Confirmed that chick, mouse, and human lymphocytes satisfy theoretical criteria for rigid, non-conducting spheres under appropriate aperture conditions.
  • Human blood lymphocyte diameters followed a normal distribution (p > 98%), whereas their volumes, surface areas, chick lymphocytes, and leukemic human lymphocytes deviated from normality.

Cite This Study

Ben‐Sasson et al. (1974) studied this question.

synapsesocial.com/papers/6a8566a7d8017c721f4e1c2bhttps://doi.org/10.1002/jcp.1040840207
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Studies on Lymphopoiesis. VII. Size Distribution of Bovine Thoracic Duct Lymphocytes.1966 · 20 citations
  2. 2Volume Distribution and Separation of Normal Human Leucocytes.1967 · 58 citations
  3. 3Dynamic osmotic behavior of chick blood lymphocytes1974 · 38 citations