Engineering Virus Functionalities on Colloidal Polyelectrolyte Lipid Composites

Engineered from the inside out: Polyelectrolyte-multilayered colloids were prepared employing the layer-by-layer technology. A lipid bilayer was then added, and finally rubella-like particles were fused. Immunofluorescence studies demonstrate that the colloidal biocomposites have a virus-like surface. Indeed, they were taken up into cells, while particles with an outer lipid layer were rarely found inside cells.