Omentin-1 Levels and Outcomes in Incident Peritoneal Dialysis Patients

Rationale & Objective Omentin-1 is an adipokine with anti-inflammatory and cardioprotective properties. The objective of this study was to determine the prognostic role of plasma omentin-1 levels in incident peritoneal dialysis (PD) patients. Study Design Retrospective analysis of prospective cohort. Setting & Participants 152 incident PD patients. Predictors Plasma omentin-1 level, adipose tissue omentin-1 messenger RNA (mRNA) expression. Outcomes Patient survival, technique survival, hospital admission, and duration of stay. Analytical Approach Time-to-event survival analyses; linear regression for hospitalization. Results The mean age was 58.4±11.7 years; 102 were men, and 92 had diabetes. There was no significant correlation between plasma omentin-1 level and its adipose tissue mRNA expression. A higher plasma omentin-1 level quartile was not associated with patient survival ( P =0.92) or technique survival ( P =0.83) but had a modest correlation with a lower number of hospital admissions ( P =0.07) and shorter duration of hospital stay ( P =0.04). In adjusted models using multivariable linear regression, a higher plasma omentin-1 level quartile remained significantly associated with fewer hospital admissions (β, -0.13; 95% CI, -0.26 to -0.002; P =0.05) and shorter hospitalization duration (β, -0.20; 95% CI, -0.38 to -0.02; P =0.03). Limitations Observational study with baseline measures only. Conclusions Plasma omentin-1 level was not associated with patient survival, technique survival, or peritonitis, but higher plasma omentin-1 levels were associated with fewer hospital admissions and shorter duration of hospitalization among incident PD patients.