Why the study?
Does FKBP10 knockdown reduce primary human lung fibroblast adhesion and migration?
Population
Primary human lung fibroblasts (phLF)
Comparison
FKBP10 knockdown using siRNA in the absence or… vs Control
Design
Preclinical
Authors
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May support FKBP10 targeting in IPF; leaves open clinical translation and efficacy.
Does FKBP10 knockdown reduce primary human lung fibroblast adhesion and migration?
FKBP10 interacts with collagen VI and its deficiency reduces primary human lung fibroblast migration by downregulating collagen VI synthesis, supporting FKBP10 as a potential drug target in idiopathic pulmonary fibrosis.
Knüppel et al. (2018) studied this question.
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