Why the study?
Does colchicine inhibit isoflurane-induced myocardial preconditioning in a rabbit model of ischemia-reperfusion?
Population
Propofol-anesthetized rabbits subjected to 30 min of anterolateral coronary occlusion followed by 3 h of…
Comparison
Colchicine 2 mg/kg intravenously before… vs Control group, isoflurane-preconditioned group…
Design
Preclinical
Follow-up
3 hours of reperfusion
Authors
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Colchicine may negate isoflurane preconditioning in rabbits; leaves open whether microtubular integrity is required for anesthetic cardioprotection in patients.
Does colchicine inhibit isoflurane-induced myocardial preconditioning in a rabbit model of ischemia-reperfusion?
Colchicine abolishes the cardioprotective preconditioning effect of isoflurane in a rabbit model, indicating that an intact microtubular cytoskeleton is required for volatile anesthetic-induced preconditioning.
Ismaeil et al. (1999) studied this question.
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