What question did this study set out to answer?

The study aims to evaluate the impact of different anesthetic agents on myocardial infarction in ischemic rabbit hearts.

March 1, 1997AnesthesiologyOpen Access

Volatile Anesthetics Protect the Ischemic Rabbit Myocardium from Infarction

Q: What is the clinical evidence from this study?

Population: Myocardial infarction. Intervention: Volatile anesthetics (halothane, enflurane, isoflurane) vs. Intravenous anesthetics (pentobarbital, ketamine-xylazine, propofol). Primary outcome: Infarct size.

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Key result

Volatile anesthetics reduced infarct size by about one half compared to intravenous agents in rabbit hearts subjected to ischemia-reperfusion.

Why the study?

Do volatile anesthetics reduce infarct size in rabbit hearts subjected to ischemia-reperfusion compared to intravenous anesthetics?

Population

Rabbit hearts (in vitro and in situ models) subjected to a standardized regional ischemia-reperfusion insult

Comparison

Volatile anesthetics vs Intravenous anesthetics or untreated isolated…

Design

Preclinical

Authors

DCDoris K. CopeAlbert Einstein College of Medicine KIKeyser W. ImpastatoUniversity of South Alabama MCMichael V. CohenEast Tennessee State University

Discussion

Member takes

Implication

Should not change anesthetic selection in patients; leaves open translation of volatile cardioprotection to human ischemia-reperfusion.

Key Points

The study aims to evaluate the impact of different anesthetic agents on myocardial infarction in ischemic rabbit hearts.
Used both in vitro and in situ rabbit models to assess infarct size due to anesthetics.
In situ preparations tested intravenous and inhalational agents; isolated hearts tested only inhalational agents.
Evaluated the role of adenosine receptors and protein kinase C in mediating protective effects.
Infarcts in halothane, enflurane, and isoflurane groups were roughly 50% smaller than those in pentobarbital, ketamine-xylazine, and propofol groups.
Adenosine receptor blockade and protein kinase C inhibition negated halothane's cardioprotective effects.
Halothane did not increase adenosine release, indicating alternative protective mechanisms.

Structured PICO

Do volatile anesthetics reduce infarct size in rabbit hearts subjected to ischemia-reperfusion compared to intravenous anesthetics?

Population

Rabbit models subjected to regional ischemia-reperfusion to evaluate the effects of anesthetic agents on infarct size.

Intervention

Volatile anesthetics (halothane, enflurane, isoflurane)

Comparator

Intravenous anesthetics (pentobarbital, ketamine-xylazine, propofol) or untreated isolated hearts

Outcome

Infarct size determined by triphenyltetrazolium chloride stainingsurrogate

Volatile anesthetics protect the ischemic rabbit heart from infarction via mechanisms dependent on adenosine receptors and protein kinase C, similar to ischemic preconditioning.

Cite This Study

Cope et al. (1997) studied Myocardial infarction. Volatile anesthetics (halothane, enflurane, isoflurane) vs. Intravenous anesthetics (pentobarbital, ketamine-xylazine, propofol) was evaluated on Infarct size. Volatile anesthetics reduced infarct size by about one half compared to intravenous agents in rabbit hearts subjected to ischemia-reperfusion.

synapsesocial.com/papers/6a5f8a871ef15e70f159729f https://doi.org/10.1097/00000542-199703000-00023

Topics

Women and heart disease

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Volatile Anesthetics Protect the Ischemic Rabbit Myocardium from Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Volatile Anesthetics Protect the Ischemic Rabbit Myocardium from Infarction

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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