Key result
Volatile anesthetics reduced infarct size by about one half compared to intravenous agents in rabbit hearts subjected to ischemia-reperfusion.
Why the study?
Do volatile anesthetics reduce infarct size in rabbit hearts subjected to ischemia-reperfusion compared to intravenous anesthetics?
Do volatile anesthetics reduce infarct size in rabbit hearts subjected to ischemia-reperfusion compared to intravenous anesthetics?
Volatile anesthetics protect the ischemic rabbit heart from infarction via mechanisms dependent on adenosine receptors and protein kinase C, similar to ischemic preconditioning.
Authors
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Should not change anesthetic selection in patients; leaves open translation of volatile cardioprotection to human ischemia-reperfusion.
Cope et al. (1997) studied Myocardial infarction. Volatile anesthetics (halothane, enflurane, isoflurane) vs. Intravenous anesthetics (pentobarbital, ketamine-xylazine, propofol) was evaluated on Infarct size. Volatile anesthetics reduced infarct size by about one half compared to intravenous agents in rabbit hearts subjected to ischemia-reperfusion.
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