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August 24, 2006AnesthesiologyOpen Access

Role of the β1-Adrenergic Pathway in Anesthetic and Ischemic Preconditioning against Myocardial Infarction in the Rabbit Heart In Vivo 

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Why the study?

Does the beta1-adrenergic pathway mediate anesthetic and ischemic preconditioning against myocardial infarction in an in vivo rabbit model?

Population

Pentobarbital-anesthetized rabbits subjected to 30 min of coronary artery occlusion and 3 h of reperfusion

Comparison

Desflurane, sevoflurane, or ischemic… vs Vehicle (control)

Design

Preclinical

Follow-up

3 hours of reperfusion

Authors

MLMarkus LangeInstitut für Arbeitsschutz der Deutschen Gesetzlichen UnfallversicherungTSThorsten M. SmulKlinikum PassauCBChristoph A. BlomeyerMedical College of Wisconsin

Discussion

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Implication

Beta1-blockade may blunt anesthetic preconditioning in experimental models; leaves open pathway relevance and translation to human perioperative protection.

Structured PICO

Does the beta1-adrenergic pathway mediate anesthetic and ischemic preconditioning against myocardial infarction in an in vivo rabbit model?

P
Population
Pentobarbital-anesthetized (30 mg/kg) rabbits (n = 96) subjected to 30 min of coronary artery occlusion and 3 h of reperfusion
I
Intervention
Desflurane (1.0 MAC), sevoflurane, or ischemic preconditioning (single 5-min cycle), with or without esmolol (30.0 mg/kg/h) or H-89 (250 microg/kg)
C
Comparator
Vehicle (control)
O
Outcome
Myocardial infarct size (triphenyltetrazolium staining) as a percentage of area at risksurrogate

Anesthetic preconditioning is mediated by the beta1-adrenergic pathway, whereas this pathway is not essential for ischemic preconditioning in a rabbit model of myocardial infarction.

Cite This Study

Lange et al. (2006) studied this question.

synapsesocial.com/papers/6a1df053871ff5209bef9227https://doi.org/10.1097/00000542-200609000-00014
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms of Desflurane-induced Preconditioning in Isolated Human Right Atria In Vitro2002 · 100 citations
  2. 2Protein Kinase C Translocation and Src Protein Tyrosine Kinase Activation Mediate Isoflurane-induced Preconditioning In Vivo2004 · 85 citations
  3. 3PI 3-kinase, protein kinase C, and protein kinase A are involved in the trigger phase of β1-adrenergic preconditioning2005 · 43 citations
  4. 4?- but not ?-adrenergic receptors precondition the ischemic heart by a staurosporine-sensitive, chelerythrine-insensitive mechanism2004 · 56 citations
  5. 5The negative inotropic effect of esmolol on isolated cardiac muscle2005 · 22 citations