Why the study?
Does disruption of actin microfilaments affect the responsiveness of cardiac KATP channels to sulfonylurea drugs in guinea pig ventricular myocytes?
Population
Single-channel currents in the inside-out configuration of excised patches from guinea pig ventricular…
Comparison
Deoxyribonuclease I applied to the internal side… vs Before DNase treatment, or DNase…
Design
Preclinical
Authors
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Actin disruption may modulate sulfonylurea effects on cardiac KATP channels in vitro; leaves open relevance to clinical use or in vivo models.
Does disruption of actin microfilaments affect the responsiveness of cardiac KATP channels to sulfonylurea drugs in guinea pig ventricular myocytes?
Disruption of actin microfilaments by DNase I antagonizes the inhibitory effect of sulfonylureas on cardiac KATP channels, suggesting regulation via subsarcolemmal actin networks.
Brady et al. (1996) studied this question.
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