Neisserial Opa Proteins: Impact on Colonization, Dissemination and Immunity

The pathogenic Neisseria sp. encode a family of phase-variable and antigenically distinct Opa proteins that allow bacterial attachment to virtually every cell type encountered during infection. Some Opa variants bind cell surface-expressed heparan sulfate proteoglycans, including members of the syndecan family of receptors, and extracellular matrix proteins such as fibronectin and vitronectin. Other variants bind members of the carcinoembryonic antigen family of cellular adhesion molecules. Depending on the Opa variant(s) expressed, these receptor interactions can allow neisserial entry and transcellular transcytosis across polarized epithelial cell monolayers, entry into endothelial cells, suppression of lymphocyte function and/or bacterial engulfment and killing by neutrophils. Recent advances in our understanding of how these Opa protein-mediated interactions influence the host cellular response are discussed in the context of their impact on various stages of neisserial infection.