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May 1, 1993HeartOpen Access

Anticardiolipin antibodies in ischaemic heart disease: marker or myth?

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Why the study?

Are anticardiolipin antibody concentrations elevated in or predictive of complications in patients with acute myocardial infarction or unstable angina?

Population

467 patients under 60 years old admitted to the coronary care unit, including 307 with acute myocardial…

Comparison

Measurement of anticardiolipin antibody… vs Age-matched controls

Design

Cohort

Follow-up

12 months (for myocardial infarction patients)

Authors

KPKavya PhadkeRochester Institute of TechnologyRPRobert A. PhillipsThe University of QueenslandDCDaniel ClarkeENT and Allergy

Discussion

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Implication

Anticardiolipin antibodies show no elevation or predictive value in acute MI or unstable angina; observational data leaves open their relevance in other thrombotic settings.

Structured PICO

Are anticardiolipin antibody concentrations elevated in or predictive of complications in patients with acute myocardial infarction or unstable angina?

P
Population
467 patients under 60 years old admitted to the coronary care unit, including 307 with acute myocardial infarction and 160 with unstable angina.
I
Intervention
Measurement of anticardiolipin antibody concentrations
C
Comparator
Age-matched controls
O
Outcome
Anticardiolipin antibody concentrations and their relationship to history of angina/myocardial infarction and subsequent cardiovascular complicationssurrogate

Anticardiolipin antibodies are not significantly associated with acute myocardial infarction or unstable angina, nor do they predict subsequent cardiovascular complications.

Cite This Study

Phadke et al. (1993) studied this question.

synapsesocial.com/papers/6a85693835bc0eada8d59c9ehttps://doi.org/10.1136/hrt.69.5.391

Topics

Women and heart disease
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Antiphospholipid Anti-Bodies—Autoantibodies with a Difference1988 · 146 citations