Why the study?
Restenosis rates are high in diabetics after angioplasty, and while sulfonylurea receptors exist in vascular smooth muscle cells, data on the exact effects of sulfonylureas on vascular smooth muscle cell proliferation and migration were lacking.
Do glibenclamide, glimepiride, and gliclazide differentially affect the proliferation and migration of vascular smooth muscle cells?
Do glibenclamide, glimepiride, and gliclazide differentially affect the proliferation and migration of vascular smooth muscle cells?
Gliclazide inhibits VSMC proliferation and migration, suggesting a potential advantage over glibenclamide and glimepiride in preventing vascular obstructive diseases in type 2 diabetes.
Answers are grounded in this paper and cite their sources.
Should not yet change sulfonylurea selection in diabetes; leaves open clinical translation of VSMC effects.
BACKGROUND/AIMS: Diabetes affects the entire vascular system and accelerates atherosclerosis and ischemia. Percutaneous transluminal angioplasty with or without stenting is the main therapeutic strategies; however, the restenosis rate is high in diabetics. Sulfonylureas (SUs) are widely prescribed agents for the treatment of type 2 diabetes (T2DM) and function by interacting with sulfonylurea receptors (SURs), which also exists in vascular smooth muscle cells (VSMCs), give rise to the potential that SUs influence VSMCs. The proliferation and migration of VSMCs play important roles in the formations of primary stenosis and restenosis, especially the latter. However, there are no data about the exact effects of SUs on these processes. METHODS: channel in these processes. RESULTS: channel. CONCLUSION: channels play an important part in proliferation and migration of VSMCs induced by glibenclamide and glimepiride. In contrast, the inhibitory effect of gliclazide on VSMCs appeared to have more potential for the prevention of vascular obstructive diseases in T2DM.
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Zhang et al. (2019) studied this question.
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