August 21, 2007AJP Endocrinology and Metabolism
Beneficial effects of GLP-1 on endothelial function in humans: dampening by glyburide but not by glimepiride
Key result
GLP-1 enhanced acetylcholine-mediated vasodilatation in healthy subjects (P<0.03), an effect that was abolished by glyburide but preserved with glimepiride (P<0.04).
Why the study?
Does the addition of glyburide or glimepiride to GLP-1 alter GLP-1-induced changes in endothelial function in healthy adults?
Population
29 healthy, nondiabetic, normotensive, nonsmoking adults, age 18-50 years with no family history of diabetes.
Comparison
Intravenous infusion of GLP-1 following oral… vs Intravenous infusion of GLP-1 following oral…
Design
RCT, Subjects were randomized to either placebo, 10 mg of glyburide, or 4 mg…
Follow-up
240 min
Authors
Discussion
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Implication
GLP-1 endothelial benefits are preserved with glimepiride but abolished by glyburide; extends mechanistic data on sulfonylurea-GLP-1 interactions in humans.
Study Design
Type
RCT (n=29)
Randomization
randomized
Structured PICO
Does the addition of glyburide or glimepiride to GLP-1 alter GLP-1-induced changes in endothelial function in healthy adults?
P
Population
29 healthy, nondiabetic, normotensive, nonsmoking adults aged 18-50 years with no family history of diabetes.
I
Intervention
Intravenous infusion of GLP-1 following oral administration of either 10 mg glyburide or 4 mg glimepiride, during a 240-min euglycemic somatostatin pancreatic clamp.
C
Comparator
Intravenous infusion of GLP-1 following oral placebo, during a 240-min euglycemic somatostatin pancreatic clamp.
O
Outcome
Acetylcholine (Ach)-mediated vasodilatation (change in forearm blood flow measured by venous occlusion plethysmography).surrogate
Main Result
p-value: p=<0.03
GLP-1 improves endothelium-dependent vasodilatation, an effect that is preserved when co-administered with glimepiride but abolished by glyburide.
Cite This Study
Basu et al. (2007) conducted an RCT in Healthy, nondiabetic (n=29). GLP-1 infusion with sulfonylureas (glyburide or glimepiride) vs. GLP-1 infusion with placebo was evaluated on Acetylcholine (Ach)-mediated vasodilatation (change from baseline forearm blood flow) (p=<0.03). GLP-1 enhanced acetylcholine-mediated vasodilatation in healthy subjects (P<0.03), an effect that was abolished by glyburide but preserved with glimepiride (P<0.04).