Why the study?
Cardiorenal syndrome is clinically recognised but poorly characterised, motivating the establishment of a valid representative model of Type 2 cardiorenal syndrome.
Population
Lewis rats
Comparison
Permanent left ventricular infarction induced by left anterior descending coronary artery ligation
Design
Preclinical animal model study
Follow-up
90-days
Authors
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Hypothesis-generating for PVN-targeted interventions in cardiorenal syndrome; leaves open translation beyond this rat model.
This study establishes a rat model of Type-2 cardiorenal syndrome following myocardial infarction, highlighting the potential role of hypothalamic paraventricular nucleus changes as a pharmacological target.
Harrison et al. (2020) studied this question.
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