March 17, 2011AJP Renal Physiology

(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism

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Population

Human embryonic kidney cells (HEK)

Design

Preclinical

Follow-up

24 h

Authors

NCNicolas ClavreulServier (France)PSPatricia Sansilvestri‐MorelAVL (France)DMDelphine MagardServier (France)

Discussion

Member takes

Implication

PRR-Nox4 pathway may drive renin-induced renal fibrosis independent of Ang II; hypothesis-generating and requires in vivo confirmation before clinical consideration.

Structured PICO

Population

Human embryonic kidney cells (HEK)

Intervention

Exposure to renin or prorenin for 24 h in the presence of a blocking concentration of perindoprilate; transfection with siRNA targeting the (pro)renin receptor (PRR) or Nox4

Outcome

Superoxide anion production, Nox4 expression, and fibrosis gene expression (TGF-β, fibronectin, and PAI-1)surrogate

Renin and prorenin promote profibrotic gene expression in human embryonic kidney cells through a PRR and Nox4-dependent mechanism, independent of angiotensin II.

Cite This Study

Clavreul et al. (2011) studied this question.

synapsesocial.com/papers/6a856a3cfc70cb81dc202707 https://doi.org/10.1152/ajprenal.00119.2010

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Implication

PRR-Nox4 pathway may drive renin-induced renal fibrosis independent of Ang II; hypothesis-generating and requires in vivo confirmation before clinical consideration.

(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

(Pro)renin promotes fibrosis gene expression in HEK cells through a Nox4-dependent mechanism

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider