Why the study?
Does angiotensin II blockade with captopril or DuP 753 restore renal functional reserve in rats with Goldblatt hypertension?
Population
Rats with two-kidney, one clip Goldblatt hypertension (1 month post-clipping) and normal rats
Comparison
Captopril or DuP 753 administered 5 days before… vs Untreated Goldblatt hypertensive rats and normal…
Design
Preclinical
Follow-up
5 days of treatment
Authors
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Angiotensin II blockade may normalize proximal reabsorption in experimental hypertension; leaves open non-Ang II factors limiting glomerular reserve.
Does angiotensin II blockade with captopril or DuP 753 restore renal functional reserve in rats with Goldblatt hypertension?
In Goldblatt hypertensive rats, inhibitory angiotensin II activity decreases proximal reabsorption during glycine, but factors other than angiotensin II limit the glomerular response to glycine.
Nicola et al. (1992) studied this question.
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