Why the study?
The local renin-angiotensin system plays an important role in prostate cancer, but the influence of the less known active peptides Ang-(1-9) and Ang-(3-7) on prostate cancer cells remained to be examined.
Ang-(1-9) and Ang-(3-7) modulate inflammatory and steroidogenesis pathway genes, affecting the biological properties of prostate cancer cells in vitro.
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Hypothesis-generating for angiotensin fragments in prostate cancer; requires in vivo validation before clinical consideration.
Domińska et al. (2020) studied this question.
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