Why the study?
Does telmisartan prevent renal injury in Angiotensin II type 1 receptor-deficient mice independent of Angiotensin II type 1 receptor blockade?
Population
Angiotensin II type 1 receptor-deficient mice with renal injury induced by unilateral ureteral obstruction
Comparison
Telmisartan vs Losartan
Design
Preclinical
Authors
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Should not change clinical practice; extends preclinical evidence for PPARγ/HGF-mediated renoprotection independent of AT1 blockade.
Does telmisartan prevent renal injury in Angiotensin II type 1 receptor-deficient mice independent of Angiotensin II type 1 receptor blockade?
Telmisartan exerts renoprotective and antifibrotic effects through the PPARγ/HGF pathway, independent of its Angiotensin II type 1 receptor blocking activity.
Kusunoki et al. (2012) studied this question.
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