Population
Cultured rat cortical neurons
Comparison
Stretch-induced mechanical injury vs Uninjured neurons (implied)
Design
Preclinical
Authors
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Hypothesis-generating for NMDA-mediated calcium dysregulation in TBI; requires in vivo validation before any clinical consideration.
Mechanical injury reduces Mg2+ blockade of NMDA receptors in cortical neurons, which may account for secondary pathological changes in traumatic brain injury.
Zhang et al. (1996) studied this question.
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