May 1, 1970British Journal of PharmacologyOpen Access

Nonspecific supersensitivity of the guinea‐pig vas deferens produced by decentralization and reserpine treatment

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Population

Guinea-pig vas deferens in vitro model

Comparison

Decentralization and reserpine treatment for 1… vs Untreated state / baseline

Design

Preclinical

Follow-up

Up to 5 days

Authors

DWD P WestfallWest Virginia University JBJ. H. BurnCourtauld Institute of Art

Discussion

Member takes

Implication

Should not alter reserpine use in humans; extends preclinical evidence for nonspecific supersensitivity in smooth muscle.

Structured PICO

Population

Guinea-pig vas deferens in vitro model

Intervention

Decentralization and reserpine treatment (1.0 mg/kg daily) for 1 or 5 days

Comparator

Untreated state / baseline

Outcome

Sensitivity of the vas deferens to noradrenaline, histamine, methylfurmethide, and potassiumsurrogate

Chronic reserpine treatment and decentralization induce nonspecific supersensitivity in the guinea-pig vas deferens, the magnitude of which is inversely related to the slope of the agonist dose-response curve.

Cite This Study

Westfall et al. (1970) studied this question.

synapsesocial.com/papers/6a856e876615ae7d6e4e201c https://doi.org/10.1111/j.1476-5381.1970.tb09560.x

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