January 1, 2012Clinical and Developmental ImmunologyOpen Access

Immunological Evaluation and Comparison of Different EV71 Vaccine Candidates

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Population

Mice and rabbits (preclinical models)

Design

Preclinical

Authors

ACAi-Hsiang ChouNational Health Research Institutes CLChia‐Chyi LiuNational United University JCJui-Yuan Chang

Discussion

Member takes

Implication

Suggests a bivalent formulation is necessary for broad hand, foot, and.

Structured PICO

Population

Mice and rabbits (preclinical models)

Intervention

Different EV71 vaccine candidates including VP1 peptide with CFA/IFA, recombinant virus-like particles with CFA/IFA, individual recombinant EV71 antigens (VP1, VP2, VP3) with CFA/IFA, and formalin-inactivated EV71 in alum

Outcome

Virus neutralizing antibody response (titer)surrogate

A combination of formalin-inactivated EV71 and CAV16 virions is suggested as the best formulation for a cost-effective HFMD vaccine based on immunogenicity profiles.

Cite This Study

Chou et al. (2012) studied this question.

synapsesocial.com/papers/6a856fdebeaf5c5b09108f72 https://doi.org/10.1155/2012/831282

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Immunological Evaluation and Comparison of Different EV71 Vaccine Candidates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Immunological Evaluation and Comparison of Different EV71 Vaccine Candidates

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider