Heparin‐Induced Thrombocytopenia: Treatment Options and Special Considerations

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Structured PICO

Population

Patients with or at risk for Heparin-Induced Thrombocytopenia (HIT)

Intervention

Alternative anticoagulant therapy (direct thrombin inhibitors: argatroban, lepirudin, bivalirudin)

This review outlines the diagnosis and management of HIT, emphasizing the prompt cessation of heparin and use of direct thrombin inhibitors.

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Supports HIT management protocols; leaves open comparative efficacy trials of direct thrombin inhibitors.

Dager et al. (2007) studied this question.

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