Key result
Combined prophylactic therapy with amiodarone and magnesium sulphate significantly reduced peri- and post-operative dysrhythmias to 16.7% compared to 37.4% with magnesium sulphate alone.
Why the study?
To compare the effectiveness of combining magnesium sulphate with amiodarone versus magnesium sulphate alone to prevent cardiac arrhythmias in CABG patients.
Does combined prophylactic therapy with amiodarone and magnesium sulphate reduce cardiac dysrhythmias in patients undergoing CABG compared to magnesium sulphate alone?
Does combined prophylactic therapy with amiodarone and magnesium sulphate reduce cardiac dysrhythmias in patients undergoing CABG compared to magnesium sulphate alone?
Absolute Event Rate: 16.7% vs 37.4%
Absolute Risk Reduction: 21%
p-value: p=<0.001
Combined prophylactic therapy with amiodarone and magnesium sulphate significantly reduced peri- and post-operative dysrhythmias in patients undergoing CABG compared to magnesium sulphate alone.
May reduce post-CABG dysrhythmias with combination prophylaxis; leaves open confirmation via randomized trials.
Objective: To compare the effectiveness of combining Magnesium Sulphate with Amiodarone vs Magnesium Sulphate to prevent cardiac arrhythmias in Coronary Artery Bypass Grafting (CABG) patients. Study Design: Quasi-Experimental Study. Place and Duration of Study: Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan, from Jul 2022 to Mar 2023. Methodology: Two hundred and sixty-two (n=262) Coronary Artery Bypass Graft patients, eligible for the study, wereenrolled through consecutive sampling and divided into group A - experiment group (3 mg/kg amiodarone+30 mg/kg magnesium sulphate was given, n1=131) and group B- control group (30 mg/kg magnesium sulphate was given, n2=131) by non-random allocation lottery method at the removal of the aortic cross-clamp. The statistical package for social science, SPSS version 26:00 was used to analyse the data. Mean±SD was calculated for continuous variables whereas for categorical variables, percentages and frequencies were calculated. Chi-square test was utilized to find the association and student t-test was applied to find the mean difference between the study groups. Results: Study participants consisted of 194(74.1%) males and 68(26.0%) females. The patients' mean age was 57.29±9.88 years and 58.30±10.69 years respectively, in group-A and group-B. The frequency of pre and post-operative cardiac dysrhythmias was considerably different in both groups. In group-A, 22(16.7%) patients developed dysrhythmias, while in control group,dysrhythmias occurred in 49 (37.4%) patients (p-value <0.001). Conclusion: Combined prophylactic therapy with amiodarone and magnesium sulphate significantly reduced the per and post-operative dysrhythmias in CABG surgeries.
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Farooq et al. (2023) studied Coronary Artery Bypass Grafting (CABG) (n=262). Amiodarone and Magnesium Sulphate vs. 30 mg/kg magnesium sulphate was evaluated on Cardiac dysrhythmias (intra-operatively and within first 72 hours post-operatively) (p=<0.001). Combined prophylactic therapy with amiodarone and magnesium sulphate significantly reduced peri- and post-operative dysrhythmias to 16.7% compared to 37.4% with magnesium sulphate alone.
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