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January 1, 2010Journal of Atherosclerosis and ThrombosisOpen Access

Association of low ankle-brachial index with mortality in patients with ischemic heart disease

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Why the study?

Does a low ankle-brachial index predict all-cause and cardiovascular mortality in patients with ischemic heart disease?

Population

1,800 Chinese patients aged ≥35 years with ischemic heart disease, mean age 68.3, 47.7% women.

Comparison

Low ankle-brachial index vs Normal ankle-brachial index (ABI ≥1.1)

Design

Cohort

Follow-up

median 38 months

Authors

LZLiqiang ZhengInternational Peace Maternity & Child Health HospitalJLJue LiBeijing Center for Disease Prevention and ControlDHDayi HuPreventive Cardiology

Discussion

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Member takes

Implication

Supports ABI for mortality risk stratification in IHD; leaves open whether measurement improves outcomes in prospective trials.

Structured PICO

Does a low ankle-brachial index predict all-cause and cardiovascular mortality in patients with ischemic heart disease?

P
Population
1,800 Chinese patients aged ≥35 years with ischemic heart disease (angina pectoris and/or myocardial infarction), mean age 68.3, 47.7% women.
I
Intervention
Low ankle-brachial index (ABI <0.9, or categorized into <0.7, 0.7-0.9, 0.9-1.1)
C
Comparator
Normal ankle-brachial index (ABI ≥1.1)
O
Outcome
All-cause mortality and cardiovascular mortality at median 38 months follow-uphard clinical

A low ankle-brachial index is independently associated with increased all-cause and cardiovascular mortality in patients with ischemic heart disease, improving risk prediction beyond conventional factors.

Limitations

  • Hospital-based setting may introduce selection bias
  • Altered prescription patterns of medications since baseline may have changed the risk of mortality
  • Lack of information on left ventricular ejection fraction (LVEF) at baseline

Cite This Study

Zheng et al. (2010) studied this question.

synapsesocial.com/papers/6a85781bfc70cb81dc202adahttps://doi.org/10.5551/jat.4093

Topics

Women and heart disease
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