Why the study?
What are the synovial fluid levels of phenylbutazone relative to plasma levels in patients?
What are the synovial fluid levels of phenylbutazone relative to plasma levels in patients?
Phenylbutazone penetrates into synovial fluid, achieving levels proportional to plasma concentrations.
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Phenylbutazone reaches substantial synovial concentrations; cross-sectional data leaves open whether this informs clinical dosing in arthritis.
Phenylbutazone was measured in the synovial fluid of 15 patients and found to be present in appreciable amounts which were related to plasma levels. 2. 80% of fluid levels were between 55% and 80% of those in plasma. 3. There was some evidence that in very actively inflamed joints phenylbutazone levels were lower. 4. There was no relationship to plasma or synovial fluid protein levels. 5. Phenylbutazone was found in one patient's synovial fluid three weeks after stopping the drug.
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Farr et al. (1977) studied this question.
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