Key result
This review provides a diagnostic algorithm for evaluating inherited platelet disorders and discusses recent advances in pathophysiology, genetic associations, and treatment options.
This review provides a diagnostic algorithm and overview of pathophysiology, genetics, and treatments for inherited platelet disorders.
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May support diagnostic evaluation of inherited platelet disorders; leaves open prospective validation of the algorithm and advances.
Inherited platelet disorders (IPDs) comprise a heterogenous group of diseases that include defects in platelet function and disordered megakaryopoiesis. Some IPDs overlap as both defects in function and thrombopoiesis, resulting in both altered aggregation and/or secretion and thrombocytopenia. This review examines the key features of the presentation of IPDs in children and adults and presents a diagnostic algorithm for the evaluation of these patients. In addition, recent advances in our understanding of the pathophysiology of platelet disorders are addressed, with attention given to some of the novel genetic associations. Finally, treatment options and future therapies are briefly discussed.
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Michele P. Lambert (2011) conducted a review in Inherited platelet disorders. This review provides a diagnostic algorithm for evaluating inherited platelet disorders and discusses recent advances in pathophysiology, genetic associations, and treatment options.
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