Key result
An integrative framework across five domains is proposed to combine established physiological measures with novel molecular biomarkers and digital technologies to advance longevity science.
Why the study?
Established physiological measures are increasingly presented as novel longevity biomarkers without acknowledging their foundational research, highlighting the need for an integrative framework.
This perspective proposes a framework for integrative longevity science, emphasizing the combination of established physiological measures with novel molecular biomarkers and digital health technologies.
Established measures risk being overlooked in longevity claims; leaves open optimal integration with emerging biomarkers.
The longevity research field is experiencing unprecedented momentum, driven by advances in molecular biomarkers, digital health technologies, and artificial intelligence. However, established physiological measures—VO 2 max, heart rate variability, body composition, muscle strength, among others—with decades of validation are increasingly presented as novel “longevity biomarkers” without acknowledging their foundational research. This perspective proposes integration as the constructive path forward, creating multidimensional aging models that combine functional measures, molecular biomarkers, mechanistic studies, and longitudinal outcomes. We present a practical framework across five domains—endpoint definition, biomarker validation, integration strategy, study design, and communication—to guide the field from rediscovery to meaningful innovation. Longevity science’s future depends on methodological rigor, transparent communication, and genuine integration of established knowledge with novel insights, ensuring that enthusiasm for new technologies translates into demonstrable improvements in healthspan and potentially lifespan.
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Marta González‐Freire (2026) studied Aging and longevity. Integrative longevity science framework was evaluated. An integrative framework across five domains is proposed to combine established physiological measures with novel molecular biomarkers and digital technologies to advance longevity science.
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