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August 1, 1998Journal of Biological ChemistryOpen Access

Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

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Authors

JHJudy B. de HaanBaker Heart and Diabetes InstituteCBCécile BladierInstitut Gustave RoussyPGPeter GriffithsUniversity of Southampton

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Cite This Study

Haan et al. (1998) studied this question.

synapsesocial.com/papers/6a8579a868d2ad262cd5977bhttps://doi.org/10.1074/jbc.273.35.22528
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Oxidative Stress: Oxidants and Antioxidants.1992 · 1,187 citations
  2. 2A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses.1995 · 383 citations
  3. 3Elevation in the Ratio of Cu/Zn-Superoxide Dismutase to Glutathione Peroxidase Activity Induces Features of Cellular Senescence and This Effect Is Mediated by Hydrogen Peroxide1996 · 234 citations