Why the study?
Are systolic time intervals altered in adolescents with insulin-dependent diabetes mellitus compared to healthy controls?
Are systolic time intervals altered in adolescents with insulin-dependent diabetes mellitus compared to healthy controls?
Cardiac contractility, as measured by systolic time intervals, is not detectably abnormal in young adolescents with insulin-dependent diabetes mellitus.
Cardiac contractility appears preserved by most systolic time intervals in adolescents with insulin-dependent diabetes; leaves open relevance of isolated QS2I prolongation.
Systolic time intervals were used to evaluate left ventricular performance in 20 diabetic adolescents with a mean age of 15.2 +/- 2.2 years (range 9-17 years) and were compared with an age- and sex-matched control group. Pre-ejection period index (PEPI), left ventricular ejection time index (LVETI), total electromechanical systole index (QS2I) and the PEP to LVET ratio were calculated at rest and following sustained isometric handgrip (SIHG). None of the diabetics had demonstrable microangiopathy or autonomic neuropathy. There was no significant difference in resting or post-exercise heart rate, PEPI, LVETI or PEP/LVET ratio between the two groups. QS2I was significantly prolonged (p less than 0.05) at rest in the diabetics, but was not significantly different following SIHG. These results indicate that cardiac contractility is not detectably abnormal in young diabetics, compared to their adult counterparts who may develop impaired myocardial performance.
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Northcote et al. (1985) studied this question.
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