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SUMMARY Cytogenetic studies have ascertained that the segregation of the X -chromosome, during the first meiotic division of the oocyte in XO mice, occurs at random, contrary to the finding of some earlier authors. The ratio of nullo- X to X -bearing oocytes at ovulation does not change with maternal age. The usefulness of the XO mouse as a model for aneuploidy production in women (Lyon & Hawker, 1973) is discussed.
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J. David Brook (1983) studied this question.
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