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This research aims to identify mitophagy-related biomarkers and their genetic relevance in colorectal cancer (CRC).

May 13, 2026Genetics ResearchOpen Access

Identification and Validation of Mitophagy‐Related Biomarkers in Colorectal Cancer: An Integrated Analysis of Single‐Cell Transcriptome and Mendelian Randomization

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Integrated analysis identifies mitophagy-related biomarkers in colorectal cancer, suggesting links to genetic causation.

This research aims to identify mitophagy-related biomarkers and their genetic relevance in colorectal cancer (CRC).
Integrated analysis of single-cell RNA sequencing and Mendelian randomization
Differential expression and machine learning utilized to identify biomarkers
Validation of gene expression through quantitative PCR in clinical samples
Identified 147 mitophagy-related differentially expressed genes (DE-MPGs)
Three biomarkers: SGCE, ATP8B2, and RANGAP1 showed significant expression changes in CRC
Mendelian randomization analysis revealed genetic causal relevance for identified biomarkers.

Zhao et al. (2026) studied this question.

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