What question did this study set out to answer?

To evaluate the endocrine effects of the dopamine agonist lergotrile mesylate on basal and stimulated anterior pituitary hormone secretion and blood chemistry in humans.

August 1, 1978The Journal of Clinical Endocrinology & Metabolism

Effect of the Dopamine Agonist, Lergotrile Mesylate, on Circulating Anterior Pituitary Hormones in Man*

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Authors

MTMichael O. ThornerLumos Pharma (United States)SRSusan M. RyanUniversity of Iowa JWJohn WassSouthern Illinois University Carbondale

Discussion

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Implication

Interventional study reveals lergotrile suppresses prolactin and stimulates growth hormone in humans, indicating potential clinical utility for neuroendocrine disorders with rapid action.

Key Points

To evaluate the endocrine effects of the dopamine agonist lergotrile mesylate on basal and stimulated anterior pituitary hormone secretion and blood chemistry in humans.
Administered 2 mg oral lergotrile mesylate to 6 normal males to assess basal and TRH- or GnRH-stimulated PRL, GH, TSH, LH, FSH, cortisol, and glucose levels, testing dopamine receptor involvement via metoclopramide antagonism in 3 subjects.
Assessed serum GH and PRL responses to single oral doses of 2 mg lergotrile compared to 2.5 mg bromocriptine in 8 patients with acromegaly and 2 patients with idiopathic hyperprolactinemia.
In healthy males, lergotrile reduced basal PRL by 90 minutes and blunted TRH-stimulated PRL release (mean peak 8.3 ± 1.1 µg/L vs. control 66.6 ± 11.3 µg/L).
Serum GH increased in 5 of 6 normal males to peaks of 8–49 µg/L compared to 2–8 µg/L after placebo, an effect blocked by metoclopramide pretreatment.
In acromegalic and hyperprolactinemic patients, lergotrile achieved an earlier onset and shorter duration of GH and PRL suppression compared to bromocriptine.

Cite This Study

Thorner et al. (1978) studied this question.

synapsesocial.com/papers/6a8582d502a1bc3ea31e61df https://doi.org/10.1210/jcem-47-2-372

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Implication

Interventional study reveals lergotrile suppresses prolactin and stimulates growth hormone in humans, indicating potential clinical utility for neuroendocrine disorders with rapid action.

Effect of the Dopamine Agonist, Lergotrile Mesylate, on Circulating Anterior Pituitary Hormones in Man*

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of the Dopamine Agonist, Lergotrile Mesylate, on Circulating Anterior Pituitary Hormones in Man*

Discussion

Member takes

Implication

Key Points

Cite This Study

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