What question did this study set out to answer?

Identify tumor-progenitor genes shared between normal embryonic kidney development and blastema-enriched Wilms tumor models.

June 15, 2006Cancer Research

Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney

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Authors

BDBenjamin DekelTel Aviv University SMSally MetsuyanimBar-Ilan University KSKai M. Schmidt‐OttMedizinische Hochschule Hannover

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Implication

Gene expression profiling reveals upregulation of imprinted and stemness genes in Wilms tumor progenitors, suggesting embryonic renewal programs drive kidney tumorigenesis.

Key Points

Identify tumor-progenitor genes shared between normal embryonic kidney development and blastema-enriched Wilms tumor models.
Analyzed gene expression profiles via oligonucleotide microarrays across Wilms tumor xenografts (WISH-WT), primary Wilms tumors, human fetal and adult kidneys, and renal cell carcinomas.
Validated candidate gene expression using real-time PCR across independent tumor specimens, developing mouse kidneys, rat metanephric blastema, and an adult mouse ischemia/reperfusion injury model.
Identified significant upregulation of paternally expressed imprinted genes (PEG1/MEST, PEG3, PEG5/NNAT, PEG10, IGF2, DLK1) and stemness homeobox genes (MEIS1, MEIS2) in blastema-rich xenografts and human fetal kidneys.
Observed rapid downregulation of PEG3, DLK1, and MEIS1 upon in vitro blastema differentiation, whereas acute ischemia/reperfusion injury in adult mouse kidneys reinduced their expression.

Cite This Study

Dekel et al. (2006) studied this question.

synapsesocial.com/papers/6a8583a56f8d490ba41e63a7 https://doi.org/10.1158/0008-5472.can-05-4528

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Implication

Gene expression profiling reveals upregulation of imprinted and stemness genes in Wilms tumor progenitors, suggesting embryonic renewal programs drive kidney tumorigenesis.

Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney

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Key Points

Cite This Study

Multiple Imprinted and Stemness Genes Provide a Link between Normal and Tumor Progenitor Cells of the Developing Human Kidney

Discussion

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Implication

Key Points

Cite This Study

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