Key result
Chronic kidney disease was associated with a statistically significant increase in serum resistin levels compared to normal control subjects.
Why the study?
Is serum resistin level significantly higher in CKD patients compared to normal individuals?
Case-Control (n=193)
Is serum resistin level significantly higher in CKD patients compared to normal individuals?
Serum resistin levels are significantly elevated in patients with chronic kidney disease compared to healthy controls, potentially linking CKD to insulin resistance.
No immediate change to CKD management; leaves open resistin as a metabolic biomarker pending prospective validation.
BACKGROUND: Chronic Kidney Diseases (CKD) of all etiologies are usually associated with Insulin Resistance (IR). Resistin is also a protein associated with IR. Some studies conducted abroad have shown that resistin level is higher among CKD patients. OBJECTIVE: To test if serum resistin level is significantly higher in CKD patients compared to normal individuals. PATIENTS AND METHODS: 96 CKD patients and 97 normal individuals were included in the study. Written informed consent was obtained from every individual. RESULTS: Serum resistin level was higher in CKD patients compared to control subjects. The difference in serum resistin level between two groups was statistically significant. CONCLUSION: Our study is probably the first study in India comparing serum resistin levels of CKD patients vis-à-vis control subjects. Further cellular research may be needed to explore this relation.
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ADITYA et al. (2014) conducted a case-control in Chronic Kidney Disease (n=193). Chronic Kidney Disease vs. Normal individuals was evaluated on Serum resistin level. Chronic kidney disease was associated with a statistically significant increase in serum resistin levels compared to normal control subjects.
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