Key result
Hemodialysis patients had increased serum leptin, adiponectin, and resistin compared to controls, while pre-dialysis patients had increased leptin but decreased adiponectin and resistin.
Why the study?
Many adipokines play an important role in endothelial dysfunction, inflammation, and oxidative stress in renal failure, but their changes needed evaluation in CKD patients with and without hemodialysis.
How do serum levels of leptin, adiponectin, and resistin differ among CKD patients with hemodialysis, CKD patients without hemodialysis, and healthy controls?
Observational (n=90)
No
How do serum levels of leptin, adiponectin, and resistin differ among CKD patients with hemodialysis, CKD patients without hemodialysis, and healthy controls?
Answers are grounded in this paper and cite their sources.
Adipokine levels (leptin, adiponectin, resistin) are significantly altered in CKD patients, with more pronounced changes observed in those undergoing hemodialysis compared to pre-dialysis patients.
Chronic kidney disease (CKD) is major and urgent public health problem caused by a progressive reduce in renal function during some months or years which cause functional or structural abnormalities of the kidney. In renal failure, many adipokines are important in endothelial dysfunction, like inflammation and oxidative stress. This study aims to evaluate the changes of some adipokines in chronic kidney disease (CKD) with and without hemodialysis (HD) Patients. Blood samples were collected from dialysis Unit in Tikrit Teaching Hospital in Tikrit city which started from January- July 2024 who aged (18 - 68) years old. The study subjects were 90 individuals who consist of 30 healthy individuals, 30 CKD patients with hemodialysis treatment and 30 CKD patients without hemodialysis treatment. The present study showed that leptin, adiponectin and resistin were increased in CKD patients with HD and (adiponectin and resistin) were decreased in CKD patients without HD while leptin was increased in CKD patients without HD when compared with control group. Adipokines changes in hemodialysis patients rather than pre dialysis CKD patients.
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Jasim et al. (2025) conducted an observational in Chronic kidney disease (n=90). Chronic kidney disease with or without hemodialysis vs. Healthy individuals was evaluated on Serum levels of leptin, adiponectin, and resistin. Hemodialysis patients had increased serum leptin, adiponectin, and resistin compared to controls, while pre-dialysis patients had increased leptin but decreased adiponectin and resistin.
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