Key result
Major depressive disorder in youth was significantly associated with lower high-frequency band heart rate variability compared to healthy controls (MD -470.138).
Why the study?
Heart rate variability has emerged as a potential physiological indicator for depression, but its association with depression symptoms in youth required exploration.
Is the high-frequency band of heart rate variability associated with depression symptoms in youth?
Case-Control (n=118)
No
Is the high-frequency band of heart rate variability associated with depression symptoms in youth?
Mean Difference: -470.138 (95% CI -748.533–-191.742)
p-value: p=0.023
The high-frequency band of heart rate variability is significantly associated with depression symptoms in youth, suggesting its potential as a physiological screening tool.
Hypothesis-generating for HRV as youth depression biomarker; prospective trials needed before clinical adoption.
Background We try to explore the association between depression symptoms and HRV parameters in youth, due to the Heart rate variability (HRV) has emerged as a potential physiological indicator for depression. Methods A total of 118 participants diagnosis with MDD and a healthy control group were recruited. HRV measurements were recorded using the Bodychecker, and an animal experiment was conducted to validate the clinical findings. Results Our results showed a significant association between youth depression symptoms and the high-frequency (HF) band of HRV in both clinical and animal data. Conclusion These findings suggested the potential of the HF band as a screening tool for youth depression.
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Zhong et al. (2023) conducted a case-control in Major depressive disorder (n=118). Major depressive disorder vs. Healthy controls was evaluated on High-frequency (HF) band of heart rate variability (MD -470.138, 95% CI -748.533 to -191.742, p=0.023). Major depressive disorder in youth was significantly associated with lower high-frequency band heart rate variability compared to healthy controls (MD -470.138).
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