Key result
Elevated serum NT-proBNP was significantly associated with ischemic stroke (OR 2.047), suggesting it is a highly useful biomarker for early diagnosis, particularly related to atrial fibrillation.
Why the study?
To summarize serum candidate markers associated with cardiovascular disease and AF that enable early diagnosis of ischemic stroke and compare their effect sizes.
Meta-Analysis
NT-proBNP appears to be a useful serum biomarker for the early diagnosis of ischemic stroke, primarily as a marker of atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Serum markers may aid early ischemic stroke detection in AF; leaves open which warrant prospective validation before clinical use.
Ischemic stroke is caused by an occlusion by a thrombus or embolus in a cerebral artery, preventing oxygenated blood from reaching the brain and causing the necrosis of nerve cells. This paper summarizes the serum candidate markers associated with cardiovascular disease and atrial fibrillation (AF) disease that enable an early diagnosis of ischemic stroke studied thus far and compares the odds ratio (OR) of each marker. This study examined the effect size of these serum candidate markers using meta-analysis techniques. The academic database search screening for articles containing the keywords “cardiovascular disease,” “atrial fibrillation,” “ischemic stroke,” and “serum marker” was limited to results for patients with ischemic stroke. The most derived markers in this study were N-terminal pro-B-type natriuretic peptide (NT-pro-BNP), D-dimer, C-reactive protein (CRP), and glial fibrillary acidic protein (GFAP), the rest being investigated individually. In conclusion, NT-pro-BNP appears to be very useful for the early diagnosis of ischemic stroke. Primarily, it is a marker of AF, and more AF markers will be uncovered and studied in the future.
No takes yet. Share an insight, caveat, or question.
Woo et al. (2022) conducted a meta-analysis in Ischemic stroke. NT-proBNP vs. Lower levels or absence of biomarker was evaluated on Association with ischemic stroke (diagnostic odds ratio) (OR 2.047, 95% CI 1.217-3.443). Elevated serum NT-proBNP was significantly associated with ischemic stroke (OR 2.047), suggesting it is a highly useful biomarker for early diagnosis, particularly related to atrial fibrillation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: