Key result
Higher pre-ablation levels of BNP and NT-proBNP are significantly associated with a greater likelihood of atrial fibrillation recurrence in non-heart failure patients undergoing catheter ablation.
Why the study?
Catheter ablation for AF carries risks and recurrent AF is common, creating a need for non-invasive markers to stratify patients by likelihood of procedural success.
Do elevated pre-ablation BNP or NT-proBNP levels predict atrial fibrillation recurrence in non-heart failure patients undergoing catheter ablation?
Systematic Review (n=1,184)
Do elevated pre-ablation BNP or NT-proBNP levels predict atrial fibrillation recurrence in non-heart failure patients undergoing catheter ablation?
Elevated pre-ablation levels of BNP and NT-proBNP are associated with a greater likelihood of atrial fibrillation recurrence following catheter ablation in patients without heart failure.
May inform pre-ablation risk stratification for AF recurrence in non-HF patients; reinforces natriuretic peptide predictive value and supports prospective validation.
Atrial Fibrillation (AF) is a growing public health issue, associated with significant morbidity and mortality. In addition to pharmacological therapy, catheter ablation is an effective strategy in restoring and maintaining sinus rhythm. However, ablation is not without risk, and AF recurs in a significant proportion of patients. Non-invasive, easily accessible markers or indices that could stratify patients depending on the likelihood of a successful outcome following ablation would allow us to select the most appropriate patients for the procedure, reducing the AF recurrence rate and exposure to potentially life-threatening risks. There has been much attention paid to Brain Natriuretic Peptide (BNP) and N-Terminal prohormone of Brain Natriuretic Peptide (NT-proBNP) as possible predictive markers of successful ablation. Several studies have demonstrated an association between higher pre-ablation levels of these peptides, and a greater likelihood of AF recurrence. Therefore, there may be a role for measuring brain natriuretic peptides levels when selecting patients for catheter ablation.
No takes yet. Share an insight, caveat, or question.
Παπαγεωργίου et al. (2019) conducted a systematic review in Atrial Fibrillation (n=1,184). Elevated pre-ablation BNP and NT-proBNP levels vs. Lower pre-ablation BNP and NT-proBNP levels was evaluated on Atrial fibrillation recurrence after catheter ablation. Higher pre-ablation levels of BNP and NT-proBNP are significantly associated with a greater likelihood of atrial fibrillation recurrence in non-heart failure patients undergoing catheter ablation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: