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The fungistatic activities of certain compounds structurally related to salicylanilide suggest the possible involvement of hydrogen bonding of the anilide hydrogen atom and chelation by the phenolic and amidic oxygen atoms with an enzyme(s)/enzyme system of the fungus. The inhibition of enzymes has been followed through the development of specific color reactions on salicylanilide assay plates. The participation of sulphydryl groups in the mechanism of action is suggested by these tests.
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Baichwal et al. (1960) studied this question.
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