In vitro study demonstrates enhanced cell proliferation and matrix gene expression in endothelial and fibroblast models, suggesting therapeutic potential for wound healing.
Key Points
To evaluate the regenerative effects of Cydonia oblonga seed mucilage on endothelial and fibroblast cell viability, migration, and extracellular matrix formation.
Treated human umbilical vein endothelial cells (HUVECs) and mouse L929 fibroblasts with Cydonia oblonga seed mucilage across a concentration range of 0.15–0.90 mg/mL over 72 hours.
Evaluated cell viability, proliferation, and scratch-wound closure alongside quantitative PCR analysis of extracellular matrix- and inflammation-related gene expression.
Mucilage significantly increased cell viability, proliferation, and wound closure in both cell types in a dose- and time-dependent manner.