The ultrastructure of tissues from 23 cases of Hodgkin's disease is described. The atypical neoplastic reticulum cell or Hodgkin cell has several features that suggest that it is of macrophage lineage. Rings of small lymphocytes are found round the neoplastic reticulum cell; less often macrophage processes are found closely related to it. The features may be those of a lymphoreticular reaction to the neoplastic reticulum cells. The fibrosis may also represent a host reaction.
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Ian Carr (1975) studied this question.
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