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Summary. The elimination of 1 ml Cr 5 ‐ 1 labelled, D‐positive, ABO‐compatible foetal erythrocytes by 200 μg of intravenously applied immunoglobulin G anti‐D was followed in 9 d‐negative probands. The red cells were quickly removed to the spleen, resulting in an erythrocyte half‐time of between 3 and 6 h. Deposition in other organs was not observed. None of the probands showed active formation of anti‐D antibody at 3 and 7 month afterwards. The intravenously applicable immunoglobulin G anti‐D therefore compares favourably with other preparations currently in use for intramuscular application. The mode of action of antibody mediated suppression of the immune response is discussed.
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Börner et al. (1969) studied this question.
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