April 22, 2003The Journal of PhysiologyOpen Access

Upregulation of Swelling‐Activated Cl⁻ Channel Sensitivity to Cell Volume by Activation of EGF Receptors in Murine Mammary Cells

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Population

Mouse mammary C127 cells (control and transfected with the full genome of the bovine papilloma virus [BPV])

Comparison

Hypotonic challenge, EGF peptides, PDGF… vs Control C127 cells or untreated cells

Design

Preclinical

Authors

IAIskandar F. AbdullaevAlbany Medical Center Hospital RSRavshan Z. SabirovNational University of Uzbekistan YOYasunobu OkadaElectrophysiology

Discussion

Member takes

Implication

Hypothesis-generating for EGF regulation of volume-sensitive Cl- channels; leaves open any cardiac in vivo relevance or therapeutic implications.

Structured PICO

Population

Mouse mammary C127 cells (control and transfected with the full genome of the bovine papilloma virus [BPV])

Intervention

Hypotonic challenge, EGF peptides, PDGF peptides, and tyrosine kinase inhibitors (tyrphostin B46, tyrphostin AG1296)

Comparator

Control C127 cells or untreated cells

Outcome

Activation and volume sensitivity of outwardly rectifying Cl- currents (VSOR Cl- currents)surrogate

EGF receptor tyrosine kinase upregulates the activity of volume-sensitive outwardly rectifying Cl- channels by enhancing their sensitivity to cell volume.

Cite This Study

Abdullaev et al. (2003) studied this question.

synapsesocial.com/papers/6a8590aaf047f857d83db2fc https://doi.org/10.1113/jphysiol.2003.039784

View Full Paper

Ask AI

Bookmark

Implication

Hypothesis-generating for EGF regulation of volume-sensitive Cl- channels; leaves open any cardiac in vivo relevance or therapeutic implications.

Upregulation of Swelling‐Activated Cl⁻ Channel Sensitivity to Cell Volume by Activation of EGF Receptors in Murine Mammary Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Upregulation of Swelling‐Activated Cl⁻ Channel Sensitivity to Cell Volume by Activation of EGF Receptors in Murine Mammary Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider